abstract：BACKGROUND:Vascular hyporeactivity in severe hemorrhagic shock could induce refractory hypotension and is an important cause of death. The global acute inflammatory response induced in shock triggers the over-expression of reactive oxygen species, NO, ET1 and TNF-α, which play essential roles in the pathology of vascul...

journal_title：Microvascular research

authors： Chen D,Song MQ,Liu YJ,Xue YK,Cheng P,Zheng H,Chen LB

更新日期：2016-05-01 00:00:00

abstract：:Diabetes mellitus (DM) leads to the development of microvascular diseases and is associated with impaired angiogenesis. The presence of vascular endothelial growth factor (VEGF) can block PDGF-BB dependent regulation of neovascularization and vessel normalization. We tested the hypothesis that the inhibition of VEGF i...

journal_title：Microvascular research

authors： Xiao L,Yan K,Yang Y,Chen N,Li Y,Deng X,Wang L,Liu Y,Mu L,Li R,Luo M,Ren M,Wu J

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Hypertension and hypercholesterolemia elicit inflammatory and thrombogenic responses in the microvasculature. However, little is known about whether and how risk factor combinations alter microvascular function. We examined how the actions of HTN+HCh on the microvasculature differ from the responses elicited ...

journal_title：Microvascular research

authors： Yildirim A,Senchenkova E,Granger DN

更新日期：2016-05-01 00:00:00

abstract：:Hyperoxia and hyperbaric oxygen therapy can restore oxygen tensions in tissues distressed by ischemic injury and poor vascularization and is believed to also yield angiogenesis and regulate tissue perfusion. The aim of this study was to develop a model in which hyperoxia-driven microvascular changes could be quantifie...

journal_title：Microvascular research

authors： Milstein DM,Helmers R,Hackmann S,Belterman CN,van Hulst RA,de Lange J

更新日期：2016-05-01 00:00:00

abstract：:Microvascular dysfunction contributes to the development of cardiovascular and metabolic disease. This study tested the hypothesis that young obese (BMI>30 kg m(-2)), otherwise healthy, adults (N=15) have impaired microvascular function relative to age and sex matched, lean (BMI<25 kg m(-2)) individuals (N=14). Partic...

journal_title：Microvascular research

authors： Patik JC,Christmas KM,Hurr C,Brothers RM

更新日期：2016-03-01 00:00:00

abstract：:This paper proposes a mathematical model for vessel recruitment in the microvascular coronary network. The model is based on microvascular network units (MVNUs), where we define a MVNU as a portion of the microvascular network comprising seven generations of identical, parallel-arranged vessels (upstream arteries, lar...

journal_title：Microvascular research

authors： Saracco A,Bauckneht M,Verna E,Ghiringhelli S,Repetto R,Sambuceti G,Provasoli S,Storace M

更新日期：2016-03-01 00:00:00

abstract：:H2O2 mediates autocrine and paracrine signaling in the vasculature and can propagate endothelial dysfunction. However, it is not clear how endothelial cells withstand H2O2 exposure and promote H2O2-induced vascular remodeling. To understand the innate ability of endothelial cells for sustaining excess H2O2 exposure, w...

journal_title：Microvascular research

authors： Patel H,Chen J,Kavdia M

更新日期：2016-01-01 00:00:00

abstract：:The electrokinetically modulated peristaltic transport of power-law fluids through a narrow confinement in the form of a deformable tube is investigated. The fluid is considered to be divided into two regions - a non-Newtonian core region (described by the power-law behavior) which is surrounded by a thin wall-adherin...

journal_title：Microvascular research

authors： Goswami P,Chakraborty J,Bandopadhyay A,Chakraborty S

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS:Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospe...

journal_title：Microvascular research

authors： Ingegnoli F,Boracchi P,Gualtierotti R,Smith V,Cutolo M,Foeldvari I,EUSTAR co-authors.

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The proepicardium (PE), a transient embryonic structure crucial for the development of the epicardium and heart, contains its own population of endothelial cells (ECs). The aim of our study was to determine the pattern, anatomical orientation and phenotypic marker expression of the endothelial cell network w...

journal_title：Microvascular research

authors： Niderla-Bielińska J,Gula G,Flaht-Zabost A,Jankowska-Steifer E,Czarnowska E,Radomska-Leśniewska DM,Ciszek B,Ratajska A

更新日期：2015-11-01 00:00:00

abstract：:Pericytes are perivascular support cells, the origin of which in tumor tissue is not clear. Recently, we identified a Tie1(+) precursor cell that differentiates into vascular smooth muscle, in a Notch-dependent manner. To understand the involvement of Notch in the ontogeny of tumor pericytes we used a novel flow immun...

journal_title：Microvascular research

authors： Patenaude A,Woerher S,Umlandt P,Wong F,Ibrahim R,Kyle A,Unger S,Fuller M,Parker J,Minchinton A,Eaves CJ,Karsan A

更新日期：2015-09-01 00:00:00

abstract：:Since the internal carotid artery supplies blood to both the eye and the brain, ocular microvascular hemodynamics can be altered due to ischemic stroke. The purpose of the current study was to establish the feasibility of conjunctival microcirculation imaging for detection of inter-ocular differences in microvascular ...

journal_title：Microvascular research

authors： Kord Valeshabad A,Wanek J,Mukarram F,Zelkha R,Testai FD,Shahidi M

更新日期：2015-07-01 00:00:00

abstract：:Particle adhesion in vivo is highly dependent on the microvascular environment comprising of unique anatomical, geometrical, physiological fluid flow conditions and cell-particle and cell-cell interactions. Hence, proper design of vascular-targeted drug carriers that efficiently deliver therapeutics to the targeted ce...

journal_title：Microvascular research

authors： Lamberti G,Soroush F,Smith A,Kiani MF,Prabhakarpandian B,Pant K

更新日期：2015-05-01 00:00:00

abstract：:A hallmark of severe inflammation is reactive oxygen species (ROS) overproduction induced by increased inflammatory mediators secretion. During systemic inflammation, inflammation mediators circulating in the bloodstream interact with endothelial cells (ECs) raising intracellular oxidative stress at the endothelial mo...

journal_title：Microvascular research

authors： Sarmiento D,Montorfano I,Cerda O,Cáceres M,Becerra A,Cabello-Verrugio C,Elorza AA,Riedel C,Tapia P,Velásquez LA,Varela D,Simon F

更新日期：2015-03-01 00:00:00

abstract：:The aim of this study is to develop a novel non-contrast 4-dimensional MR arterial spin labeling (4D-ASL) technique (3D acquisition and time) and to investigate myocardial perfusion on healthy volunteers without administration of contrast materials. A non-contrast 4D-ASL technique was developed using the time-spatial ...

journal_title：Microvascular research

authors： Miyazaki M,Zhou X,Hoshino T,Yokoyama K,Ishimura R,Nitatori T

更新日期：2015-03-01 00:00:00

abstract：:Neovascularization is crucial for fracture healing and plays an important role in long-time graft survival in tissue engineering applications. Endothelial progenitor cells (EPCs) can be isolated from peripheral blood avoiding donor site morbidity, which makes them attractive for autologous cell-based engineering of ne...

journal_title：Microvascular research

authors： Goerke SM,Obermeyer J,Plaha J,Stark GB,Finkenzeller G

更新日期：2015-03-01 00:00:00

abstract：:Hypoxia-induced arginase elevation plays an essential role in several vascular diseases but influence of arginase on hypoxia-mediated angiogenesis is completely unknown. In this study, in vitro network formation in bovine aortic endothelial cells (BAEC) was examined after exposure to hypoxia for 24h with or without ar...

journal_title：Microvascular research

authors： Wang L,Bhatta A,Toque HA,Rojas M,Yao L,Xu Z,Patel C,Caldwell RB,Caldwell RW

更新日期：2015-03-01 00:00:00

abstract：:Nitrate supplementation in the form of beetroot juice has been shown to increase nitric oxide (NO) where nitrate can be reduced to nitrite and, subsequently, to NO through both nitric oxide synthase (NOS)-dependent and -independent pathways. We tested the hypothesis that nitrate supplementation would augment the NO co...

journal_title：Microvascular research

authors： Keen JT,Levitt EL,Hodges GJ,Wong BJ

更新日期：2015-03-01 00:00:00

abstract：:Polyphenolic compounds (anthocyanins, flavonoid glycosides) in berries prevent the initiation, promotion, and progression of carcinogenesis in rat's digestive tract and esophagus, in part, via anti-inflammatory pathways. Angiogenesis has been implicated in the pathogenesis of chronic inflammation and tumorigenesis. In...

journal_title：Microvascular research

authors： Medda R,Lyros O,Schmidt JL,Jovanovic N,Nie L,Link BJ,Otterson MF,Stoner GD,Shaker R,Rafiee P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Sepsis is a fatal systemic inflammatory response syndrome caused by severe infection. The aim of this study was to measure hepatic microcirculation during the sepsis with laser speckle contrast imaging (LSCI), as well as investigating the underlying mechanisms. METHODS:Sepsis was induced by cecal ligation a...

journal_title：Microvascular research

authors： Wu Y,Ren J,Zhou B,Ding C,Chen J,Wang G,Gu G,Liu S,Li J

更新日期：2015-01-01 00:00:00

abstract：:Visualization of the lymphatic system is clinically necessary during diagnosis or treatment of many conditions and diseases; it is used for identifying and monitoring lymphedema, for detecting metastatic lesions during cancer staging and for locating lymphatic structures so they can be spared during surgical procedure...

journal_title：Microvascular research

authors： Munn LL,Padera TP

更新日期：2014-11-01 00:00:00

abstract：:Recently the zebrafish has emerged as a promising vertebrate model of lymphatic vasculature development. The establishment of numerous transgenic lines that label the lymphatic endothelium in the zebrafish has allowed the fine examination of the developmental timing and the anatomy of their lymphatic vasculature. Alth...

journal_title：Microvascular research

authors： Mulligan TS,Weinstein BM

更新日期：2014-11-01 00:00:00

abstract：:Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, in part, by equilibrative nucleoside transporter subtype 1 (ENT1; SLC29A1) and by equilibrative nucleobase transporter ...

journal_title：Microvascular research

authors： Bone DB,Antic M,Vilas G,Hammond JR

更新日期：2014-09-01 00:00:00

abstract：:The purpose of this study was to determine whether bidirectional flow exists in the sciatic vasa nervorum. Images obtained using high-frequency color Doppler ultrasound in duplex imaging mode (Vevo 2100) were studied retroactively. In Fig. 1 (left panel; rat 1), the color Doppler signal and flow-velocity waveforms are...

journal_title：Microvascular research

authors： Olver DT,Lacefield JC,Shoemaker KJ

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:In this study we aimed to evaluate effects of liver resection on hepatic microcirculation. In addition we wanted to study if histological liver damage could be detected intra-operatively. PATIENTS AND METHODS:40 patients undergoing hepatic resection were included and grouped according to if they were operat...

journal_title：Microvascular research

authors： Nilsson J,Eriksson S,Blind PJ,Rissler P,Sturesson C

更新日期：2014-07-01 00:00:00

abstract：:Pulmonary arterial hypertension is a common complication of congenital heart defects with left-to-right shunts. Current preclinical models do not reproduce clinical characteristics of shunt-related pulmonary hypertension. Aorto-caval shunt was firstly described as a model of right ventricle volume overload. The pathop...

journal_title：Microvascular research

authors： Rungatscher A,Linardi D,Milani E,Ucci G,Nicolato E,Merigo F,Salvetti B,Mazzucco A,Luciani GB,Faggian G

更新日期：2014-07-01 00:00:00

abstract：:This study aims to assess the relationship between spontaneous oscillations in changes in cerebral tissue oxyhemoglobin concentrations (Delta [HbO2]) and arterial blood pressure (ABP) signals in healthy elderly subjects during the resting state using wavelet coherence analysis. Continuous recordings of near-infrared s...

journal_title：Microvascular research

authors： Cui R,Zhang M,Li Z,Xin Q,Lu L,Zhou W,Han Q,Gao Y

更新日期：2014-05-01 00:00:00

abstract：:Routine pulmonary ultrasound for diagnosis of disease or injury relies on interpretation of image features, such as comet-tail artifacts, which can also be indicative of the poorly understood phenomenon of ultrasound-induced pulmonary capillary hemorrhage (PCH). Evans blue extraction and bronchoalveolar lavage (BAL) w...

journal_title：Microvascular research

authors： Miller DL,Suresh MV,Dou C,Yu B,Raghavendran K

更新日期：2014-05-01 00:00:00

abstract：:Lymphangiogenesis is thought to be essential for cancer progression, making it an important target in cancer therapy. Lymphangiogenic factors (VEGF-C and VEGF-D) are upregulated in various tumors/cancers, and play an important role in lymphangiogenesis and lymph node metastasis. Similarly, semaphorin 4D (Sema4D) is a ...

journal_title：Microvascular research

authors： Liu H,Yang Y,Xiao J,Yang S,Liu Y,Kang W,Li X,Zhang F

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Endothelial cells are suggested regulators of tumor response to radiation. Anti-vascular targeting agents can enhance tumor response by targeting endothelial cells. Here, we have conducted experiments in vitro to discern the effects of radiation combined with the anti-angiogenic Sunitinib on endothelial (HUV...

journal_title：Microvascular research

authors： El Kaffas A,Al-Mahrouki A,Tran WT,Giles A,Czarnota GJ

更新日期：2014-03-01 00:00:00

abstract：:Non-freezing cold injury (NFCI) is a prevalent, but largely undiagnosed and poorly understood syndrome afflicting many who, as part of their work or leisure, expose their extremities to cold temperatures. The long term sequelae of NFCI are hyperhidrosis, cold-sensitivity and pain; these can last a lifetime. We tested ...

journal_title：Microvascular research

authors： Hope K,Eglin C,Golden F,Tipton M

更新日期：2014-01-01 00:00:00

abstract：:Thrombolysis treatment of acute ischemic stroke is limited by the pro-edematous and hemorrhagic effects exerted by reperfusion, which disrupts the blood-brain barrier (BBB) capillary endothelium in the infarct core. Most studies of the ischemic BBB overlook the complexity of the penumbral area, where the affected brai...

journal_title：Microvascular research

authors： Kuntz M,Mysiorek C,Pétrault O,Boucau MC,Aijjou R,Uzbekov R,Bérézowski V

更新日期：2014-01-01 00:00:00

abstract：:Histone acetylation/deacetylation is a key mechanism for regulating transcription, which plays an important role in the control of gene expression, tissue growth, and development. In particular, histone deacetylase 7 (HDAC7), a member of class IIa HDACs, is crucial in maintaining vascular integrity. Endothelial progen...

journal_title：Microvascular research

authors： Yu D,Chen W,Ren J,Zhang T,Yang K,Wu G,Liu H

更新日期：2014-01-01 00:00:00

abstract：:We investigated the role of nitric oxide synthase (NOS) on regional cutaneous vascular function at rest (thermoneutral conditions) and during the vasodilator response to increased local skin temperature (Tloc). Dorsal forearm and lateral leg sites were instrumented with microdialysis fibers, local heaters, and laser-D...

journal_title：Microvascular research

authors： Del Pozzi AT,Carter SJ,Collins AB,Hodges GJ

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate whether region-dependent endothelial heterogeneity is present within the porcine vortex vein system. METHODS:The superior temporal vortex vein in young adult pig eyes were dissected out and cannulated. The intact vortex vein system down to the choroidal veins was then p...

journal_title：Microvascular research

authors： Tan PE,Yu PK,Cringle SJ,Morgan WH,Yu DY

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Leukocytes play a key role in the early response to tissue injury/infection resulting from physical, chemical or biological stimuli. This process involves the initiation of the leukocyte adhesion cascade mediated by a series of interactions between receptors and ligands on the endothelium and the leukocytes. ...

journal_title：Microvascular research

authors： Lamberti G,Tang Y,Prabhakarpandian B,Wang Y,Pant K,Kiani MF,Wang B

更新日期：2013-09-01 00:00:00

abstract：:The retina provides a window to study the pathophysiology of cerebrovascular diseases. Pathological retinal microvascular changes may reflect microangiopathic processes in the brain. Recent advances in optical imaging techniques have enabled the imaging of the retinal microvasculature at the capillary level, and the g...

journal_title：Microvascular research

authors： Jiang H,Debuc DC,Rundek T,Lam BL,Wright CB,Shen M,Tao A,Wang J

更新日期：2013-09-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a combination of clinical disorders that together increase the risk for cardiovascular disease and diabetes. SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats with MetS show impaired nitric oxide-mediated relaxation in coronary and mesenteric arteries, and angiotensin II receptor type 1 blockers pr...

journal_title：Microvascular research

authors： Kagota S,Maruyama K,Tada Y,Fukushima K,Umetani K,Wakuda H,Shinozuka K

更新日期：2013-07-01 00:00:00

abstract：:Endothelial cells represent one of the critical cellular elements in tumor microenvironment playing a crucial role in the growth and progression of cancer through controlling angiogenesis. Vascular endothelial growth factor (VEGF) produced from tumor cells is essential for the expansion of breast cancer and may functi...

journal_title：Microvascular research

authors： Alvarez-García V,González A,Alonso-González C,Martínez-Campa C,Cos S

更新日期：2013-05-01 00:00:00

abstract：:Angiogenesis, or the growth of new blood vessels, is critical to both health and disease. Several genes are implicated in the regulation of angiogenesis, such as genes encoding growth factors, cytokines, and the extracellular matrix, as well as transcription factors. Among them, Hox genes exert master regulatory effec...

journal_title：Microvascular research

authors： Mahdipour E

更新日期：2013-05-01 00:00:00